Dipeptidyl peptidase 3 and thimet oligopeptidase 1 knockdown support tumor-specific immune responses to whole cell cancer vaccines and tumor cell death in vivo
نویسندگان
چکیده
Background and aims Tumor cell vaccines are widely used as a potential therapeutic. Different approaches are currently being applied to kill tumor cell vaccines prior to injection to prevent outgrowth of metastasis at the site of injection. We and others have previously shown that the mode by which tumor cells die can have significant effects on anti-tumor specific immune responses. Here, we have studied how tumor cell necrosis impairs immune responses and describe a new strategy to enhance tumor-specific immune responses to dying tumor cells.
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2013